Fu-Jen University, Taipei, Taiwan 1982/0～1986/0 Bachelor of Science, Nutrition and Food Sciences
Kansas State University, Kansas, USA 1986/0～1988/0 Master of Science, Nutrition
University of California, Berkeley, USA 1988/0～1993/0 Doctor of Philosophy, Nutritional Science & Toxicology
學術研究成果
學術期刊論文
1. Kuo CS, Huang CY, Kuo HT, Cheng CP, Chen CH, Lu CL, Yang FLO, Huang RFS*. Interrelationships among genetic C677T polymorphism of 5,10-methylenetetrahydrofolate reductase, biochemical folate status, and lymphocytic p53 oxidative damage in association with tumor malignancy and survivals of patients with hepatocellular carcinoma. Mol. Nutr. Food Res. 2013,00:1-14. (SCI:4/124, IF:4.310)
2.Wang TP, Shu CH, Fang SC, and Huang RFS*. Folate deprivation enhanced invasiveness of human colon cancer cells mediated by activation of sonic hedgehog signaling through its promoter hypomethylation and cross-action with transcription nuclear factor-kappa B pathway. Carcinogenesis. 2012;33:1158-68. (SCI:28/196, IF: 5.402 )
3.Chen TF, Huang RFS, Lin SE, Chiu MJ. Synergic effect of folic acid and memantine on spatial learning and neuronal protection in an Alzheimer’s transgenic model. J Alzheimers Dis. 2010;20:607-15. (SCI:64/251, IF:4.174 )
4. Ye YL, Chan YT, Liu HC, Lu HT, and Huang RFS*. Depleted folate pool and dysfunctional mitochondria associated with defective mitochondrial folate proteins sensitize Chinese ovary cell mutants to tert-butylhydroperoxide–induced oxidative stress and apoptosis. J Nutr Biochem. 2010 ;21(9):793-800. (SCI:8/76 , IF: 4.538)
5. Chou YF, HuangRFS*. Mitochondrial DNA deletions of blood lymphocytes as geneticmarkers of low folate-related mitochondrial genotoxicity in peripheral tissues. Euro J Nutr. 2009;48:429-36. (SCI:22/76 , IF: 3.127)
6. Wu MY , Kuo CS, Lin CY, Lu CL, HuangRFS*. Lymphocytic mitochondrial DNA deletions, biochemical folate status and hepatocellular carcinoma susceptibility in a case–control study. Br J Nutr. 2009;102:715-721.(SCI: 18/76 , IF: 3.072)
7. Kuo CS, Lin CY, Wu MY, Lu CL, Huang RFS*. Relationship between folate status and tumour progression in patients with hepatocellular carcinoma. Br J Nutr. 2008;100: 596-602. (SCI:18/76 , IF: 3.302)
8. Chou YF, Yu CC, Huang RFS*. Changes in mitochondrial (mt) DNA in folate-deficient tissues of young rats depend on mt folate, mt biogenesis, and oxidative DNA injuries. J Nutr. 2007;137:2036-2042. (SCI:10/76 , IF: 4.295)
9.Chang CM, Yu CC, Lu HT, Chou YF, Huang RFS*. Folate deprivation promotes mitochondrial oxidative decay: DNA large deletions, cytochrome c oxidase dysfunction, membrane depolarization and superoxide overproduction in rat liver. Br J Nutr. 2007;97:855-863. (SCI:18/76 , IF: 3.302)
10.Huang RF, Huang SM, Lin BS, Hung CY, Lu HT. N-Acetylcysteine, vitamin C and vitamin E diminish homocysteine thiolactone-induced apoptosis in human promyeloid HL-60 cells. J Nutr. 2002;132(8):2151-6. (SCI: , IF: 4.196)
11. Huang RF, Hsu YC, Lin HL, Yang FL. Folate depletion and elevated plasma homocysteine promote oxidative stress in rat livers. J Nutr. 2001;131(1):33-8. (SCI: , IF: 4.196)
12.Huang RF, Ho YH, Lin HL, Wei JS, Liu TZ. Folate deficiency induces a cell cycle-specific apoptosis in HepG2 cells. J Nutr. 1999;129(1):25-31. (SCI: , IF: 4.196)
5.郭常勝、許瑞芬，「Genetic C677T polymorphisms of methylenetetrahydrofolate reductase and one-carbon metabolites as prognostic predictors for survival outcome of patients with hepatocellular carcinoma.」，Boston，USA，2013年04月20日，頁D337, 1077
6. 許弘政、許瑞芬，「Treatment of late-stage Alzheimer’s disease with folate derivatives in the 3xTg-AD mice model.」，28th international conference of Alzheimer's disease international，台北，臺灣，2013年04月18日，頁P003, p130
8.馮馨醇、郭常勝、田宇峯、孫定平、李健逢、許瑞芬，「The role of folate status and methylenetetrahydrofolate reductase gene C677T polymorphism in sonic hedgehog signal and its altered methylation pattern in human colorectal carcinoma」，美國，2012年04月21日
